🍪 The GLP Lounge uses cookies to improve your experience, analyze traffic, and personalize content. By continuing to use this site, you agree to our Cookie Policy.
Evidence-based GLP-1 & peptide discussion since 2023
ForumsMASH / Liver DiseaseMASH biomarker panel — 6 month update

MASH biomarker panel — 6 month update

JenPlateau Thu, Mar 19, 2026 at 6:02 PM 8 replies 800 viewsPage 1 of 2
JenPlateau
Member
234
890
Nov 2024
Missouri
Mar 19, 2026 at 6:02 PM#1

My prescriber ordered three tests and this board recommends about twenty, and I would like to know which of those two lists is right.

The narrow version of the question is how often to repeat it, because quarterly seems to be the convention and I cannot find the reasoning.

I would rather have one careful answer than five confident ones.

42 12HPLC_Greg, LibrarianMeg, bri_stats and 39 others
Reply Quote Save Share Report
Dr.GutHealth
Senior Member
1,456
7,890
Mar 2024
Minnesota
Mar 19, 2026 at 7:56 PM#2

This one has a reasonably settled answer, so here it is. The single most useful discipline is bringing the whole panel to a clinician rather than one flagged value. One out-of-range result in isolation generates anxiety and unnecessary tests; the same result next to the trend and the rest of the panel usually generates a shrug.

41 11tyler_CSCS, VanRx_Mike, steve_okc and 38 others
Reply Quote Save Share Report
JennaRN
Senior Member
1,987
8,923
Mar 2024
Colorado
Online
Mar 19, 2026 at 9:50 PM#3
Dr.GutHealth said:
The single most useful discipline is bringing the whole panel to a clinician rather than one flagged value.

Agreed, and reference ranges are laboratory-specific. Comparing your number to somebody else's range, or to a screenshot from another country, is how people convince themselves something is wrong.

40 10BiostatsBrad, PeptideSynthNJ, Dr.KarenChen and 37 others
Reply Quote Save Share Report

Sigma-Aldrich — Research-Grade Standards

Certified reference materials, analytical reagents, and research-grade standards for peptide verification. Trusted by laboratories worldwide.

Shop Reference Standards
NurseAsh_DET
Member
356
1,567
Sep 2024
Detroit, MI
Mar 19, 2026 at 11:44 PM#4
JenPlateau said:
My prescriber ordered three tests and this board recommends about twenty, and I would like to know which of those two lists is right.

Same position here, arrived at the long way round. Quarterly for the first year is convention rather than evidence, and it is defensible for a simple reason: it is roughly the interval over which HbA1c becomes informative again, since it reflects about three months of glycaemia. After the first year, and once doses are stable, annual is reasonable unless something specific is being followed.

39 9labquiet_amy, emily_PDX, Dr.SleepRoch and 36 others
Reply Quote Save Share Report
Dr.PeteFamMed
Senior Member
2,012
9,234
Jan 2024
Minneapolis, MN
Mar 20, 2026 at 10:58 AM#5

Adding the clinical framing, because it changes how the question reads.

PSA: get baseline labs BEFORE starting baseline bloodwork therapy. You need a "before" picture to measure progress. My recommended pre-treatment panel:

  1. CMP + A1C + fasting insulin
  2. Complete lipid panel with particle count if possible
  3. hsCRP, ferritin, B12, vitamin D
  4. Thyroid panel (TSH + free T4)
  5. CBC with differential
  6. Liver panel (ALT, AST, GGT)
  7. DEXA scan or body composition

Total cost at Quest without insurance: ~$200. Worth every penny for the data.

38 8FranDenver, Dr.BariatricHTX, LindaRN_retired and 35 others
Reply Quote Save Share Report

Similar Threads

Survodutide MASH Phase 2b — histological improvement data9 replies
Semaglutide and MASH — liver fat reduction quantification13 replies
Non-invasive MASH biomarkers — FibroScan, ELF, FIB-4 on GLP-110 replies
ALT normalization rates on GLP-1 — pooled trial data20 replies
GLP-1 hepatoprotection — direct vs indirect mechanisms16 replies
ForumsNewTrendingMembersAccount

Log In

Forgot password?
No account? Register