Hypoglycemia risk with concomitant sulfonylurea use

SarahChen_PharmD said:

The nausea I get is not really nausea, it is an aversion.

Agreeing with SarahChen_PharmD, and the qualification matters more than the agreement. The line between titrate-through and stop is not severity, it is trajectory and what else is present. Nausea that peaks and improves within a week is the expected pattern. Nausea that is escalating, or that comes with severe upper-abdominal pain radiating to the back, or that prevents fluids for more than a day, is a different conversation and belongs with a clinician the same day.

Happy to go further on any of that.

SarahChen_PharmD said:

The nausea I get is not really nausea, it is an aversion.

I dislike how confidently this board tells people to push through. Incidence figures around 20 to 25% at the higher doses are class-typical, but the trials also had a discontinuation column, and "manageable with protocols" is not the same as manageable for everyone.

Taking the question as asked, rather than the general version of it. The practical protocol is dull and it works: smaller meals, stop eating at the first sign of fullness rather than at the end of the plate, drop the fat fraction of meals in the two days after dosing, and do not lie down straight after eating. Most of what people call unmanageable nausea is a meal-size and meal-composition problem interacting with a stomach that is emptying slowly.

HPLC_Greg said:

The line between titrate-through and stop is not severity, it is trajectory and what else is present.

Adding a me-too, because a thread of one person's experience is not much use. Nothing to add that would improve it.