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ForumsMASH / Liver DiseaseLiver biopsy changes on semaglutide — November 2025 Page 5

Liver biopsy changes on semaglutide — November 2025

hank_denver Fri, Apr 17, 2026 at 2:54 AM 23 replies 1,081 viewsPage 5 of 5
TrialTracker_MD
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May 4, 2026 at 9:00 AM#21

The figures, for anyone assembling their own picture. Keep the original post as written when you update it, and add the correction underneath. An edited-away mistake is invisible to the next person who makes it.

34 7Dr.EM_Chicago, pete_RVA, CarlaRPh_TPA and 31 others
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CarlaRPh_TPA
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May 9, 2026 at 3:39 PM#22

One thing that is still open after Dr.EM_Chicago’s answer:

What the dose-response curve actually looks like above 1.7mg, because the trial means hide how few people account for the extra loss?

35 8ricardo_MIA, BrianDallas92, labquiet_amy and 32 others
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pam_stl
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May 14, 2026 at 10:21 PM#23
TrialTracker_MD said:
Keep the original post as written when you update it, and add the correction underneath.

This is where I part company with the consensus forming above. I would resist the confidence. Half of what this board was certain about two years ago has since been quietly dropped, and nobody went back to correct the threads.

Happy to go further on any of that.

36 9PedsEndoPhilly, SleepDoc_PDX, RegAffairsDC and 33 others
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Dr.ObesityMed
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May 20, 2026 at 5:06 AM#24
TrialTracker_MD said:
Keep the original post as written when you update it, and add the correction underneath.

Agreed, and ALT falling is not the same as fibrosis improving. Enzymes are a crude proxy; FIB-4 or elastography is what tells you about the thing that matters.

37 10PeptideChemSF, A1cHero_PHX, Dr.RenalNash and 34 others
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Dr.RaviCardio
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May 25, 2026 at 11:54 AM#25
TrialTracker_MD said:
Keep the original post as written when you update it, and add the correction underneath.

That reframing is the part I needed. I will report back once I have actually tried it.

38 11jason_sac26, chris_chi24, tampaLisa73 and 35 others
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