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ForumsMASH / Liver DiseaseALT normalization rates on GLP-1 — looking for input Page 3

ALT normalization rates on GLP-1 — looking for input

bbq_ray_KC Mon, Apr 27, 2026 at 9:54 AM 24 replies 793 viewsPage 3 of 5
fiona_glasgow
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Apr 29, 2026 at 9:22 AM#11
Dr.AddMedPHL said:
ATTAIN trial (survodutide) context for liver and MASH: survodutide, a GLP-1/glucagon dual agonist, showed -18.7% body weight at 46 weeks in the Phase…

That reframing is the part I needed. Taking it to my next appointment.

2 0TrialTracker_MD, JennaRN
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CarlaRPh_TPA
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Apr 29, 2026 at 12:22 PM#12

Adding the clinical framing, because it changes how the question reads. The version of this that has an answer is narrower than the version being asked. Narrow it and it becomes tractable; leave it broad and the thread will produce nine confident and incompatible replies.

Ask again with the specifics and you will get a better answer than this one.

Last edited: Apr 29, 2026 at 4:22 PM
3 1ricardo_MIA, BrianDallas92, labquiet_amy
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JessicaH_TX
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Apr 29, 2026 at 3:22 PM#13
Dr.PathRoch said:
NASH/MAFLD therapeutic landscape and liver and MASH: GLP-1 agonists are emerging as potential first-line NASH therapy.

Worth saying that the confident version of this is more useful to the person writing it than to the person reading it.

4 2kim_atl_prep, sarah_TO, wendy_avl and 1 other
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labquiet_amy
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Apr 29, 2026 at 6:22 PM#14

The figures, for anyone assembling their own picture. Practical: whatever you change, write down the date and the reason. In three months the reason is what you will have forgotten, and the reason is what makes the record worth having.

Last edited: Apr 29, 2026 at 8:22 PM
5 3bri_stats, pete_manc_UK, anna.melb_AU and 2 others
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Admin
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Apr 29, 2026 at 9:22 PM#15

Moderator note: the sourcing question belongs in the vendor section and has been split out. Report rather than reply if it drifts again.

6 4PeptideSynthNJ, Dr.KarenChen, Dr.NateNeph and 3 others
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