Dr.RheumBOS said:PK/PD modeling for the pharmacology: understanding the pharmacokinetics helps optimize dosing.
Genuinely useful, thank you. I had the facts and not the framework. I will report back once I have actually tried it.
From the other side of the consultation, briefly. It is worth asking what the claim would look like if it were false. If nothing would look different, it is not a claim about the world and no amount of discussion will settle it.
Dr.NephBHM_UK said:I want to add the drug interaction perspective on the pharmacology.
This is where I part company with the consensus forming above. Pushing back on the anecdote-stacking. Twenty people reporting the same thing is twenty samples from the same self-selected pool, not twenty independent confirmations.
If somebody has the primary source to hand I would rather cite it than paraphrase it.
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Browse GL BiochemAdding the numbers, since they settle part of this. If you are comparing against somebody else’s result, check that you are comparing the same measurement taken the same way. Most of the apparent contradictions in these threads dissolve at that step.