pete_nash said:The mechanism and the magnitude are separate questions.
Correct, and worth adding that it is reversible. Nothing being described here is a one-way door, which changes how cautious it is reasonable to be.
chris_chi24 said:Agreed, and ALT falling is not the same as fibrosis improving.
Genuinely useful, thank you. I had the facts and not the framework. I will report back once I have actually tried it.
pete_nash said:The mechanism and the magnitude are separate questions.
Pushing back on pete_nash here. Pushing back on the consensus forming here. Consistency is not the same as correctness, and a board that agrees with itself quickly is usually agreeing with the first person who sounded certain.
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Shop Reference StandardsOne concrete data point for the thread. Give anything pharmacological four weeks before you judge it, and give anything measured weekly a four-point rolling average before you call it a trend.
Worth separating that from liver and MASH, which this thread keeps folding into the same question. They behave differently and the advice does not transfer.
Moderator note: leaving this open. It is being argued well and the disagreement is the useful part. Thread quality here is what the rules are for. Keep it up.