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ForumsMASH / Liver DiseaseLiver enzymes normal for the first time in a decade Page 3

Liver enzymes normal for the first time in a decade

BethLabQueen Thu, May 14, 2026 at 3:17 PM 22 replies 619 viewsPage 3 of 5
MikeFit_NJ
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May 15, 2026 at 3:29 AM#11
Dr.SurgeonPGH said:
Whatever the answer turns out to be, the method for getting there is the same: state the assumption, do the arithmetic in public, and invite the…

Fair, and it stops being fair at the extremes. The middle of the range is well understood; the ends are where the honest answer is that nobody knows.

20 18LeilaHI, marcus_mpls, DeniseRN_TPA and 17 others
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tane_welly
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May 15, 2026 at 6:32 AM#12
newstart_MO said:
ATTAIN trial (survodutide) context for liver and MASH: survodutide, a GLP-1/glucagon dual agonist, showed -18.7% body weight at 46 weeks in the Phase…

Saving this. It is the first explanation that did not require me to already understand it. Printing the relevant bit and taking it with me.

21 19carl_compliance, DanielChem_CHI, marco_milano and 18 others
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JakeSmashed95
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May 15, 2026 at 9:35 AM#13
Dr.SurgeonPGH said:
Whatever the answer turns out to be, the method for getting there is the same: state the assumption, do the arithmetic in public, and invite the…

I read this differently. The confidence in this thread is running ahead of the evidence, and I would rather the uncertainty were stated than smoothed over because it is unsatisfying.

Last edited: May 15, 2026 at 2:35 PM
22 20alex_tucson, kevin_tulsa, Dr.PainCLE and 19 others
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TirzTom
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May 15, 2026 at 12:38 PM#14

Adding the numbers, since they settle part of this. Give anything pharmacological four weeks before you judge it, and give anything measured weekly a four-point rolling average before you call it a trend.

23 21SandraNC_45, Dr.EndoIndy, tom_AK and 20 others
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mike_mod
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May 15, 2026 at 3:41 PM#15

Moderator note: leaving this open. It is being argued well and the disagreement is the useful part. Carry on.

24 22PurityPaulOR, MaxMetOK, MounjBrad and 21 others
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