chris_chi24 said:Worth answering the question that was asked rather than the one behind it.
Second this. I had assumed I was the exception until I read this.
chris_chi24 said:Worth answering the question that was asked rather than the one behind it.
There is a second half to this that has not been said yet. Albumin binding above 99% is the whole reason weekly dosing works, and it is also why the trough matters more than the peak. People who dose late are not losing a peak, they are letting the trough fall, and the appetite effect tracks the trough.
Adding the numbers, since they settle part of this. Worth knowing that the injection site changes very little. Abdomen, thigh and upper arm are bioequivalent for semaglutide, so a site change is not a plausible explanation for a bad week.
Worth separating that from semaglutide, which this thread keeps folding into the same question. They behave differently and the advice does not transfer.
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Browse GL BiochemOne thing that is still open after chris_chi24’s answer:
How much of the between-person variation is pharmacokinetic and how much is just adherence measured badly?
OP back with an update, since a thread like this is useless without one.
Update since I posted: I held at 1.7mg for a further twelve weeks and lost another 4kg slowly, which settles it for me. I was escalating because the number was available, not because I had stopped responding.