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ForumsMASH / Liver DiseaseFibrosis regression on GLP-1 — is scarring really reversible? Page 5

Fibrosis regression on GLP-1 — is scarring really reversible?

Dr.PathRoch Sat, May 30, 2026 at 3:14 PM 21 replies 557 viewsPage 5 of 5
mia_MS2
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Jun 3, 2026 at 3:27 AM#21
Dr.RenalNash said:
The version of this that has an answer is narrower than the version being asked.

Coming at Dr.RenalNash’s question from a different direction. Order of operations matters more than any single choice here: establish a baseline, change one thing, wait long enough for it to express itself, then measure again under the same conditions.

If somebody has the primary source to hand I would rather cite it than paraphrase it.

29 2ricardo_MIA, BrianDallas92, labquiet_amy and 26 others
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NicoleRaleigh
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Jun 4, 2026 at 10:07 AM#22

One concrete data point for the thread. The boring version of this is the one that works, and the boring version is: measure a baseline, change one variable, wait, measure again under the same conditions. Nobody wants that answer and it is still the answer.

Correct me if the detail matters more than I have assumed.

30 3MikeFit_NJ, InsuranceTom, WendyG_ATL and 27 others
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Dr.Martinez
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Jun 5, 2026 at 4:46 PM#23

One thing that is still open after Dr.RenalNash’s answer:

How would you tell the difference between that and the alternative explanation?

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marco_milano
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Jun 6, 2026 at 11:24 PM#24
NicoleRaleigh said:
The boring version of this is the one that works, and the boring version is: measure a baseline, change one variable, wait, measure again under the…

I read this differently from NicoleRaleigh, on substance rather than tone. Pushing back on the anecdote-stacking. Twenty people reporting the same thing is twenty samples from the same self-selected pool, not twenty independent confirmations.

Last edited: Jun 7, 2026 at 3:24 AM
32 5tammy_FL, Dr.LipidDallas, alex_tucson and 29 others
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MikeNYC_runner
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Jun 8, 2026 at 6:01 AM#25
NicoleRaleigh said:
The boring version of this is the one that works, and the boring version is: measure a baseline, change one variable, wait, measure again under the…

That is right, and it stops being right at the edges. The general case is well behaved; the interesting cases in this thread are all at the boundary where the general case breaks.

33 6MASHdoc_SA, GenomicsKate, Dr.ObesityMed and 30 others
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