Semaglutide and exercise performance — VO2max and endurance data

Taking the question as asked, rather than the general version of it. The mechanism that matters here is not stomach emptying, it is central. GLP-1 receptor agonism in the arcuate nucleus stimulates POMC neurons and suppresses AgRP/NPY signalling, which is why the effect is appetite and food salience rather than physical fullness. Delayed gastric emptying largely tachyphylaxes over the first months; the appetite effect does not.

CarlaRPh_TPA said:

The mechanism that matters here is not stomach emptying, it is central.

Agreed, though "tolerable" needs defining. A dose you tolerate by eating almost nothing is not tolerated, it is being paid for somewhere else — usually in lean mass, sometimes in adherence three months later.

RunnerRach said:

Training four times a week throughout and the scale has barely acknowledged it, which is demoralising in a way I did not expect.

That holds for the injectable. The oral formulation has different absorption behaviour and the dose numbers are not interchangeable, which is worth saying out loud because people quote them as if they were.

From the other side of the consultation, briefly.

Gym confidence after training weight loss: walked into a gym for the first time in 5 years yesterday. Was terrified. But you know what? Nobody stared. Nobody judged. Everyone was focused on their own workout.

Started with 20 minutes on the treadmill and some machine-based resistance exercises. Nothing fancy. But I DID IT. And I'll go back tomorrow.

To anyone too intimidated to start: the hardest rep is walking through the door. Everything after that is just movement. 💪