🍪 The GLP Lounge uses cookies to improve your experience, analyze traffic, and personalize content. By continuing to use this site, you agree to our Cookie Policy.
Evidence-based GLP-1 & peptide discussion since 2023
ForumsMASH / Liver DiseaseGLP-1 hepatoprotection — direct vs indirect mechanisms Page 4

GLP-1 hepatoprotection — direct vs indirect mechanisms

MASHdoc_SA Sun, Jun 7, 2026 at 4:05 PM 16 replies 402 viewsPage 4 of 4
Dr.PainCLE
Senior Member
1,234
6,234
Mar 2024
Cleveland, OH
Jun 8, 2026 at 10:30 AM#16
julia.endo said:
There is a difference between no evidence and evidence of no effect, and this subject is one where the two get swapped freely in both directions.

This matches mine closely enough to be worth saying so out loud. Nothing to add that would improve it.

Last edited: Jun 8, 2026 at 1:30 PM
37 10Dr.PathRoch, mona_PHX, andrew_nyc and 34 others
Reply Quote Save Share Report
Dr.ReproEndo
Senior Member
1,890
8,901
Jan 2024
Scottsdale, AZ
Jun 8, 2026 at 1:14 PM#17
SleepDoc_PDX said:
Give anything pharmacological four weeks before you judge it, and give anything measured weekly a four-point rolling average before you call it a…

There is a second half to this that has not been said yet. If two explanations both fit, the useful question is which one predicts something the other does not. That is answerable; arguing about which sounds more plausible is not.

38 11andrew_nyc, Dr.EndoEP, GraceAZ_72 and 35 others
Reply Quote Save Share Report
dan_philly
Member
456
2,123
Jul 2024
Philadelphia, PA
Jun 8, 2026 at 3:58 PM#18

One concrete data point for the thread. For anyone reading later: the numbers in this thread are worth checking against a primary source before you act on them, including mine. Half the figures circulating in this community trace back to a secondary summary that dropped a qualifier.

Last edited: Jun 8, 2026 at 6:58 PM
39 12SkepticalSean, Dr.CardioMD, EndoResFellow and 36 others
Reply Quote Save Share Report

Sigma-Aldrich — Research-Grade Standards

Certified reference materials, analytical reagents, and research-grade standards for peptide verification. Trusted by laboratories worldwide.

Shop Reference Standards
mike_mealprep
Member
412
1,890
Jul 2024
Chicago, IL
Jun 8, 2026 at 6:43 PM#19

One thing that is still open after SleepDoc_PDX’s answer:

Was that from a primary source or from a summary of one?

Last edited: Jun 9, 2026 at 12:43 AM
40 13mel_PDX, Dr.AddMedPHL, newstart_MO and 37 others
Reply Quote Save Share Report
Admin
Administrator
2,456
9,812
Oct 2023
Online
Jun 8, 2026 at 9:27 PM#20

Moderator note: two posts asking for a source have been merged into one. Please search the thread before asking again.

Last edited: Jun 9, 2026 at 1:27 AM
12 10PeptideSynthNJ, Dr.KarenChen, Dr.NateNeph and 9 others
Reply Quote Save Share Report

Similar Threads

Survodutide MASH Phase 2b — histological improvement data9 replies
Semaglutide and MASH — liver fat reduction quantification13 replies
Non-invasive MASH biomarkers — FibroScan, ELF, FIB-4 on GLP-110 replies
ALT normalization rates on GLP-1 — pooled trial data20 replies
MASH resolution without worsening fibrosis — endpoint analysis11 replies
ForumsNewTrendingMembersAccount

Log In

Forgot password?
No account? Register