jason_paloalto said:If you are comparing against somebody else’s result, check that you are comparing the same measurement taken the same way.
This answered a question I did not know how to ask.
Adding the clinical framing, because it changes how the question reads. The distinction that resolves most of these threads is between what is true on average and what is true for one person. Both are real; they answer different questions and get quoted as if they were the same one.
Dr.EndoIndy said:The distinction that resolves most of these threads is between what is true on average and what is true for one person.
Agreed, though "tolerable" needs defining. A dose you tolerate by eating almost nothing is not tolerated, it is being paid for somewhere else — usually in lean mass, sometimes in adherence three months later.
Worth separating that from semaglutide, which this thread keeps folding into the same question. They behave differently and the advice does not transfer.
If somebody has the primary source to hand I would rather cite it than paraphrase it.
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Browse GL BiochemDr.EndoIndy said:The distinction that resolves most of these threads is between what is true on average and what is true for one person.
Coming at Dr.EndoIndy’s question from a different direction. Steady state is the thing most people miss. The terminal half-life is about a week, so every dose step takes four to five weeks to fully express itself. Judging a step at day ten is judging the ascent, not the plateau, and it is the single commonest reason people escalate before they needed to.
Adding the numbers, since they settle part of this. Worth knowing that the injection site changes very little. Abdomen, thigh and upper arm are bioequivalent for semaglutide, so a site change is not a plausible explanation for a bad week.