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ForumsSemaglutide (Ozempic / Wegovy)Semaglutide and alcohol intolerance — mechanism and prevalence data Page 5

Semaglutide and alcohol intolerance — mechanism and prevalence data

NeuroNate Thu, Apr 30, 2026 at 9:05 AM 23 replies 623 viewsPage 5 of 5
mike_nyc
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May 4, 2026 at 2:36 AM#21

A narrower follow-up, since the general answer is now clear:

Whether the change in tolerance is the smaller stomach, the smaller body, or something central, and whether it settles?

45 18maya_sedona, stefan_berlin, Dr.EM_Chicago and 42 others
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Dr.PulmRoch
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May 5, 2026 at 12:54 AM#22
hans_munich said:
Reduced interest in alcohol is one of the most consistently reported off-target effects, and the mechanism is plausibly the same reward-salience…

Careful with the causal language. Two things moving together in a period when five things changed is not a mechanism, and stating it as one makes the thread less useful to somebody reading it later.

That is the short version; the long version is somebody else's post.

Last edited: May 5, 2026 at 1:54 AM
46 19traveltech_sara, AttorneyGrant, DebRD_ATL and 43 others
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VanRx_Mike
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May 5, 2026 at 11:11 PM#23
hans_munich said:
Reduced interest in alcohol is one of the most consistently reported off-target effects, and the mechanism is plausibly the same reward-salience…

No disagreement, though the timescale matters more than the mechanism here. Most of what looks like a difference in kind turns out to be a difference in how long somebody waited.

Last edited: May 6, 2026 at 2:11 AM
47 20Admin, Dr.Martinez, mike_mod and 44 others
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Dr.LeslieOBGYN
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May 6, 2026 at 9:28 PM#24
hans_munich said:
Reduced interest in alcohol is one of the most consistently reported off-target effects, and the mechanism is plausibly the same reward-salience…

That reframing is the part I needed. Sending this to two other people who asked me the same thing last week.

48 21NicoleRaleigh, james_edin, FranDenver and 45 others
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Dr.MetabolicMD
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May 7, 2026 at 7:44 PM#25

Clinical perspective, offered as context rather than as advice. Worth answering the question that was asked rather than the one behind it. The narrow version usually has an answer; the broad version usually does not, and answering the broad one is how a thread stops being useful.

Last edited: May 7, 2026 at 9:44 PM
49 22GenomicsKate, Dr.ObesityMed, HealthEcon_DC and 46 others
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