KPV peptide for inflammatory bowel — May 2025

TomTeleRx said:

The mechanism is slowed transit plus reduced intake, and that combination determines which interventions work.

Acid reflux and constipation: I developed GERD symptoms around week 6 that I'd never had before. The delayed gastric emptying means food and acid sit in your stomach longer.

Management that works for me: elevate head of bed 6 inches, don't eat within 3 hours of lying down, avoid trigger foods (tomato, citrus, spicy, chocolate), and famotidine 20mg at bedtime. Much better now.

One thing that is still open after roxy_nash’s answer:

What the mechanism is, because if it is transit rather than water then fiber is the wrong lever?

labquiet_amy said:

Acid reflux and constipation: I developed GERD symptoms around week 6 that I'd never had before.

Gastroparesis symptoms with constipation: the delayed gastric emptying from GLP-1 agonists can cause early satiety, bloating, and feeling "full" for hours after a small meal.

Tips: eat your protein FIRST (most important macro), then vegetables, then carbs last. Chew thoroughly — 20-30 chews per bite isn't excessive. Avoid carbonated beverages with meals. If symptoms are severe, your doctor may recommend a gastric emptying study.

Closing the loop on my own question.

Resolved: water and magnesium first, soluble fibre second, bran gone entirely. Two months of doing it in the wrong order and a week to undo.

Dr.AddMedPHL said:

Gastroparesis symptoms with constipation: the delayed gastric emptying from GLP-1 agonists can cause early satiety, bloating, and feeling "full" for…

Heartburn management on constipation: Tums as needed has been my savior. The delayed gastric emptying means stomach acid just sits there.

Don't ignore persistent heartburn — chronic acid exposure can damage your esophagus. If OTC remedies aren't cutting it after 2 weeks, see your doctor for something stronger. You shouldn't suffer through this.