Trying to work out whether my panel improved or merely rearranged itself, because two of the numbers went the wrong way.
So the question, as narrowly as I can put it: whether an unchanged LDL-C alongside a large triglyceride fall is a good result or a bad one, because ApoB and LDL-C seem to be telling different stories.
If the honest answer is that nobody knows, that is a useful answer and I would rather have it.
This one has a reasonably settled answer, so here it is. The phase 2 numbers were about 24% mean weight loss at 48 weeks on the top dose, with the curve still descending at the end of the study. A curve that has not flattened is a real finding, but it also means the true plateau is unknown, and phase 2 populations are small and selected.
FDA_TrackerJim said:The phase 2 numbers were about 24% mean weight loss at 48 weeks on the top dose, with the curve still descending at the end of the study.
Fair, but phase 2 tolerability figures rarely survive contact with phase 3 scale. Triple agonism means three receptor systems generating adverse events, and the dropout column is the one I would read first when the larger trials report.
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Browse GL BiochemDerekSJ_a1c said:Trying to work out whether my panel improved or merely rearranged itself, because two of the numbers went the wrong way.
Mine went the same way, slower.
Adding the clinical framing, because it changes how the question reads.
Omega-3 index improvement on the lipid panel: often overlooked but my omega-3 index went from 3.9% to 8.9% over 10 months. I supplemented with 2g EPA+DHA daily.
This matters because omega-3s are anti-inflammatory and cardioprotective, complementing the GLP-1 benefits. Target omega-3 index is >8%. Combined with the triglyceride reduction from the medication, my lipid profile is the best it's been in decades.