Retatrutide cholesterol effects — need advice

hyun_seoul said:

Advanced lipoprotein testing on the lipid panel — going beyond standard lipid panel: Marker Baseline Month 8 Clinical Meaning LDL-P 1535 935 Particle…

Omega-3 index improvement on the lipid panel: often overlooked but my omega-3 index went from 4.3% to 8.8% over 12 months. I supplemented with 2g EPA+DHA daily.

This matters because omega-3s are anti-inflammatory and cardioprotective, complementing the GLP-1 benefits. Target omega-3 index is >8%. Combined with the triglyceride reduction from the medication, my lipid profile is the best it's been in decades.

jason_sac26 said:

Fair, but phase 2 tolerability figures rarely survive contact with phase 3 scale.

Thank you — that is the clearest version of this I have read, and I have read a lot of them. Printing the relevant bit and taking it with me.

hyun_seoul said:

Advanced lipoprotein testing on the lipid panel — going beyond standard lipid panel: Marker Baseline Month 8 Clinical Meaning LDL-P 1535 935 Particle…

I would rather people stopped quoting the 24% as if it were a licensed outcome. It is a phase 2 result in a few hundred participants with no cardiovascular endpoint and no long-term safety data, and this board has a habit of treating pipeline numbers as settled.

labquiet_amy said:

Triglycerides dropped by half, HDL barely moved, and my calculated LDL is almost exactly where it started, which is not the outcome I had been…

Comprehensive lipid panel update relevant to the lipid panel:

The triglyceride drop is the most impressive. My cardiologist reduced my statin dose based on these results.

Moderator note: the sourcing question belongs in the vendor section and has been split out. No action needed from anybody.