Glucagon receptor agonism and hepatic lipid oxidation — need advice

ZaraB_AL said:

The part it does not cover is what to do when the honest answer is "not enough data", which is more often than anyone likes.

This matches mine closely enough to be worth saying so out loud. Nothing to add that would improve it.

ZaraB_AL said:

The part it does not cover is what to do when the honest answer is "not enough data", which is more often than anyone likes.

Adding the part of the answer the thread has not reached. The mechanism is more central than most summaries suggest. Receptor agonism in the arcuate nucleus activates POMC neurons and inhibits AgRP/NPY signalling, and the downstream MC4R pathway is the same one disrupted in monogenic obesity — convergent genetic evidence that the target is the right one. Peripherally there is glucose-dependent insulin secretion, glucagon suppression and delayed gastric emptying, but the gastric component largely adapts over months while the central effect persists, which is why the durable effect is appetite rather than fullness.

Adding the numbers, since they settle part of this. One habit that pays for itself: post the method alongside the number. A figure without its method cannot be checked, and an unchecked figure is how this community accumulates folklore.

Following on from ZaraB_AL — and this may be the naive question:

How long did you give it before you decided it was working?

hank_denver said:

One habit that pays for itself: post the method alongside the number.

Worth saying that the confident version of this is more useful to the person writing it than to the person reading it.