🍪 The GLP Lounge uses cookies to improve your experience, analyze traffic, and personalize content. By continuing to use this site, you agree to our Cookie Policy.
Evidence-based GLP-1 & peptide discussion since 2023
ForumsRetatrutide & Triple AgonistsWill reta make sema and tirz obsolete? — my results so far Page 7

Will reta make sema and tirz obsolete? — my results so far

raj_cambridge Thu, Sep 18, 2025 at 10:58 PM 45 replies 1,803 viewsPage 7 of 9
PeptideChemSF
Senior Member
1,890
9,012
Jan 2024
San Francisco, CA
Nov 1, 2025 at 11:27 AM#31

Clinical perspective, offered as context rather than as advice. There is a difference between no evidence and evidence of no effect, and this subject is one where the two get swapped freely in both directions.

Last edited: Nov 1, 2025 at 3:27 PM
2 0steve_okc, dave_SLC
Reply Quote Save Share Report
tampaLisa73
Member
312
1,456
Oct 2024
Tampa, FL
Nov 4, 2025 at 7:56 PM#32
PeptideChemSF said:
There is a difference between no evidence and evidence of no effect, and this subject is one where the two get swapped freely in both directions.

Mine went the same way, slower. I had assumed I was the exception until I read this.

3 1FitDadDave, RunnerRach, TrialNerd_Beth
Reply Quote Save Share Report
mel_PDX
Member
189
890
Dec 2024
Portland, OR
Nov 8, 2025 at 4:23 AM#33
PeptideChemSF said:
There is a difference between no evidence and evidence of no effect, and this subject is one where the two get swapped freely in both directions.

There is a second half to this that has not been said yet. Most of what circulates confidently in this community traces back to one summary of one study, and the qualifier was dropped somewhere in the third retelling.

4 2PeptideSynthNJ, Dr.KarenChen, Dr.NateNeph and 1 other
Reply Quote Save Share Report

Janoshik Analytical — Independent Testing

Trusted third-party HPLC & mass spectrometry analysis. Verify peptide purity with the lab the community relies on. Independent. Accurate. Transparent.

Verify Your Peptides

GL Biochem (Shanghai) Ltd. — Direct Manufacturer

Est. 1998. The synthesis house behind the vials you send for testing. ISO 9001 and cGMP certified, 1,500+ staff, batch-specific COA with every order.

Browse GL Biochem
bri_stats
Member
789
3,456
May 2024
Seattle, WA
Nov 11, 2025 at 12:48 PM#34

Adding the numbers, since they settle part of this. Worth stating the units and the reference range whenever you post a number here. A large fraction of the apparent disagreement in these threads is two people using different units and both being right.

Correct me if the detail matters more than I have assumed.

5 3JessicaM_2024, TomFromTexas, mike.trainer_LA and 2 others
Reply Quote Save Share Report
DadBodDave
Member
187
923
Nov 2024
Ohio
Nov 14, 2025 at 9:11 PM#35

A narrower follow-up, since the general answer is now clear:

What did you change at the same time, and can you separate the two now?

6 4JakeBK_lifts, DerekSJ_a1c, paige_pharma and 3 others
Reply Quote Save Share Report

Similar Threads

TRIUMPH-3 topline results — 24.2% body weight loss at 48 weeks10 replies
Retatrutide mechanism: GLP-1/GIP/glucagon triple agonism explained5 replies
Retatrutide Phase 2 dose-response analysis — optimal dose range10 replies
Glucagon receptor agonism and hepatic lipid oxidation — MASH implications13 replies
Retatrutide vs tirzepatide — dual vs triple agonist comparison22 replies
ForumsNewTrendingMembersAccount

Log In

Forgot password?
No account? Register