GCG receptor signaling deep dive — anyone have experience?

sarah_TO said:

There is a difference between no evidence and evidence of no effect, and this subject is one where the two get swapped freely in both directions.

Coming at sarah_TO’s question from a different direction. If two explanations both fit, the useful question is which one predicts something the other does not. That is answerable; arguing about which sounds more plausible is not.

One concrete data point for the thread. For anyone reading later: the numbers in this thread are worth checking against a primary source before you act on them, including mine. Half the figures circulating in this community trace back to a secondary summary that dropped a qualifier.

Following on from sarah_TO — and this may be the naive question:

How would you tell the difference between that and the alternative explanation?

Dr.RaviCardio said:

For anyone reading later: the numbers in this thread are worth checking against a primary source before you act on them, including mine.

Filing a mild objection. Mild because I might be wrong; an objection because nobody has addressed the case that does not fit. I would resist the confidence. Half of what this board was certain about two years ago has since been quietly dropped, and nobody went back to correct the threads.

Dr.RaviCardio said:

For anyone reading later: the numbers in this thread are worth checking against a primary source before you act on them, including mine.

Fair, and it stops being fair at the extremes. The middle of the range is well understood; the ends are where the honest answer is that nobody knows.