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ForumsLab Results & BiomarkersTestosterone changes on GLP-1 — need advice Page 5

Testosterone changes on GLP-1 — need advice

GenomicsKate Sun, Oct 19, 2025 at 5:00 PM 44 replies 1,368 viewsPage 5 of 9
SleepFixSam
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Oct 20, 2025 at 8:59 PM#21

Following on from PharmacoVig_BOS — and this may be the naive question:

Did your prescriber agree with that reading, and if not what was their objection?

19 17pete_nash, hank_denver, carlos_SATX and 16 others
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TrialTracker_MD
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Oct 21, 2025 at 3:15 AM#22
wanda_boise said:
Order of operations matters more than any single choice here: establish a baseline, change one thing, wait long enough for it to express itself, then…

Pushing back on wanda_boise here. This treats a plausible mechanism as a demonstrated one. Plausible is where you start looking, not where you stop.

Ask again with the specifics and you will get a better answer than this one.

20 18stefan_berlin, Dr.EM_Chicago, pete_RVA and 17 others
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Dr.LeslieOBGYN
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Oct 21, 2025 at 9:31 AM#23
wanda_boise said:
Order of operations matters more than any single choice here: establish a baseline, change one thing, wait long enough for it to express itself, then…

Correct, and worth adding that it is reversible. Nothing being described here is a one-way door, which changes how cautious it is reasonable to be.

21 19james_edin, FranDenver, Dr.BariatricHTX and 18 others
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Dr.AddMedPHL
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Oct 21, 2025 at 3:47 PM#24
wanda_boise said:
Order of operations matters more than any single choice here: establish a baseline, change one thing, wait long enough for it to express itself, then…

Genuinely useful, thank you. I had the facts and not the framework. Taking it to my next appointment.

22 20TomFromTexas, mike.trainer_LA, sarah_nash92 and 19 others
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james_edin
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Oct 21, 2025 at 10:03 PM#25

Clinical perspective, offered as context rather than as advice. If two explanations both fit, the useful question is which one predicts something the other does not. That is answerable; arguing about which sounds more plausible is not.

Last edited: Oct 22, 2025 at 12:03 AM
23 21bbq_ray_KC, oliver_london, tane_welly and 20 others
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