Dr.PulmRoch said:Practical: whatever you change, write down the date and the reason.
Agreed on the mechanism, with the caveat that the head-to-head used semaglutide 1mg, not 2.4mg. It is still the best direct evidence available, but it is not the comparison most people think they are citing.
Dr.PulmRoch said:Practical: whatever you change, write down the date and the reason.
This answered a question I did not know how to ask.
Adding the clinical framing, because it changes how the question reads. If two explanations both fit, the useful question is which one predicts something the other does not. That is answerable; arguing about which sounds more plausible is not.
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Browse GL Biochemroxy_nash said:If two explanations both fit, the useful question is which one predicts something the other does not.
Mine went the same way, slower. Nothing to add that would improve it.
roxy_nash said:If two explanations both fit, the useful question is which one predicts something the other does not.
Adding the part of the answer the thread has not reached. The mechanism and the magnitude are separate questions. Agreeing that something happens says nothing about whether it happens enough to act on.