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ForumsRetatrutide & Triple AgonistsGlucagon receptor agonism and hepatic lipid oxidation — looking for input Page 3

Glucagon receptor agonism and hepatic lipid oxidation — looking for input

kim_atl_prep Thu, Mar 19, 2026 at 10:24 AM 14 replies 922 viewsPage 3 of 3
Dr.NutriCornell
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Mar 24, 2026 at 10:44 AM#11
LibrarianMeg said:
There is a difference between no evidence and evidence of no effect, and this subject is one where the two get swapped freely in both directions.

Agreed, and one caution: a single measurement is not a measurement. Anything that moves day to day needs a trend before it means anything at all.

Last edited: Mar 24, 2026 at 12:44 PM
35 8emily_PDX, Dr.SleepRoch, laura_annarbor and 32 others
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Dr.EM_Chicago
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Mar 27, 2026 at 10:15 AM#12
hannah_MT said:
Agreed, and the adaptation point cuts both ways: tachyphylaxis to gastric emptying is why tolerability improves, and it is also why people who were…

Thank you — that is the clearest version of this I have read, and I have read a lot of them.

36 9matt_MKE, Dr.ReproEndo, lucas_SP_BR and 33 others
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COA_Karl
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Mar 30, 2026 at 9:47 AM#13
LibrarianMeg said:
There is a difference between no evidence and evidence of no effect, and this subject is one where the two get swapped freely in both directions.

I read this differently. The confidence in this thread is running ahead of the evidence, and I would rather the uncertainty were stated than smoothed over because it is unsatisfying.

37 10hyun_seoul, jim_asheville, matt_MKE and 34 others
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BethLabQueen
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Apr 2, 2026 at 9:21 AM#14

Adding the numbers, since they settle part of this. If you are going to change something, change one thing and give it long enough to express itself. Four weeks is the usual minimum for anything pharmacological on this board, and two weeks of data has told you almost nothing.

38 11cory_ATX, lori_vegas, Dr.PulmRoch and 35 others
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mike_mod
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Apr 5, 2026 at 8:56 AM#15

Moderator note: reminder that nothing in this thread is medical advice, and that clinical claims need a source. Tagging this one for the weekly digest.

Last edited: Apr 5, 2026 at 10:56 AM
39 12PurityPaulOR, MaxMetOK, MounjBrad and 36 others
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