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ForumsLab Results & BiomarkersFinally in the normal range for everything - first time in 20 years — anyone have experience?

Finally in the normal range for everything - first time in 20 years — anyone have experience?

marcus_mpls Sat, Jan 3, 2026 at 6:24 PM 24 replies 1,337 viewsPage 1 of 5
marcus_mpls
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Jan 3, 2026 at 6:24 PM#1

Posting this because the summary going around does not say what the paper says, and the difference matters for how people here are using it.

A defensible baseline is short: HbA1c and fasting glucose, a lipid panel with ApoB if you can get it, ALT and AST, creatinine with eGFR, TSH, ferritin and B12, and a full blood count. That set catches the things that change, the things that explain symptoms, and the things that alter the prescribing decision. Almost everything else on the long circulating lists is either invariant, uninterpretable without a specific question, or an incidental finding waiting to cause an unnecessary workup.

Where I think it is weakest: the comparator does most of the work in how this gets reported, and it is not the comparator most people think they are citing.

What I am after is what actually belongs on a baseline panel, as opposed to the enormous list that gets pasted around here. Numbers rather than impressions, if you have them.

Note on sourcing:
Figures above are from the primary publication rather than the press summary. If a number here disagrees with one you have, post yours and we will work out which of us is reading a secondary source.
26 21bbq_ray_KC, oliver_london, tane_welly and 23 others
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PharmD_Rodriguez
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Jan 3, 2026 at 6:31 PM#2
marcus_mpls said:
A defensible baseline is short: HbA1c and fasting glucose, a lipid panel with ApoB if you can get it, ALT and AST, creatinine with eGFR, TSH, ferritin…

No disagreement with marcus_mpls. One condition attached. The single most useful discipline is bringing the whole panel to a clinician rather than one flagged value. One out-of-range result in isolation generates anxiety and unnecessary tests; the same result next to the trend and the rest of the panel usually generates a shrug.

25 20TinaHashiRN, robert_kc, dan_philly and 22 others
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LipidDoc_ATL
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Jan 3, 2026 at 6:38 PM#3
marcus_mpls said:
A defensible baseline is short: HbA1c and fasting glucose, a lipid panel with ApoB if you can get it, ALT and AST, creatinine with eGFR, TSH, ferritin…

Filing a mild objection. Mild because I might be wrong; an objection because nobody has addressed the case that does not fit. I would drop the "get everything" instinct further than this thread does. Every extra test is another chance at a false positive, and incidental findings have their own cost in scans, biopsies and worry.

24 19AttorneyGrant, DebRD_ATL, KristenIndy and 21 others
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Dr.NateNeph
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Jan 3, 2026 at 6:45 PM#4

This one has a reasonably settled answer, so here it is. Quarterly for the first year is convention rather than evidence, and it is defensible for a simple reason: it is roughly the interval over which HbA1c becomes informative again, since it reflects about three months of glycaemia. After the first year, and once doses are stable, annual is reasonable unless something specific is being followed.

23 18B12Beth, RickReta_CO, PharmHunterJen and 20 others
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AttorneyGrant
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Jan 3, 2026 at 7:21 PM#5
PharmD_Rodriguez said:
The single most useful discipline is bringing the whole panel to a clinician rather than one flagged value.

Same experience, arrived at from the opposite direction.

22 17Dr.GastroMayo, JakeBK_lifts, DerekSJ_a1c and 19 others
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