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ForumsTirzepatide (Mounjaro / Zepbound)Tirzepatide nausea management — March 2026 Page 6

Tirzepatide nausea management — March 2026

DataDave Wed, Sep 11, 2024 at 9:14 PM 30 replies 2,103 viewsPage 6 of 6
RegAffairsDC
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Sep 14, 2024 at 1:16 PM#26

A narrower follow-up, since the general answer is now clear:

How long did you give it before you decided it was working?

Last edited: Sep 14, 2024 at 3:16 PM
7 5amy_econ_NJ, bbq_ray_KC, oliver_london and 4 others
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Dr.GastroMayo
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Sep 14, 2024 at 8:09 PM#27
DanielChem_CHI said:
Practical: whatever you change, write down the date and the reason.

This is where I part company with the consensus forming above. Not convinced. The evidence being cited is consistent with the conclusion and also consistent with two other conclusions nobody has ruled out.

Last edited: Sep 15, 2024 at 1:09 AM
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SleepDoc_PDX
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Sep 15, 2024 at 3:02 AM#28
DanielChem_CHI said:
Practical: whatever you change, write down the date and the reason.

Agreed on adaptation, with a caveat: adaptation applies to gastric emptying and not to everything. If your problem is the aversion rather than the fullness, waiting does less, because the aversion is central and it is the mechanism working as intended.

9 7carlos_SATX, sophie_paris, mel_PDX and 6 others
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DerekSJ_a1c
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Sep 15, 2024 at 9:55 AM#29
DanielChem_CHI said:
Practical: whatever you change, write down the date and the reason.

This is exactly what I could not find anywhere else. Taking it to my next appointment.

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DataDave
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Sep 15, 2024 at 4:47 PM#30

OP back with an update, since a thread like this is useless without one.

Holding the step for six weeks instead of four did it. Same dose, same food, and the nausea that had felt like a wall turned out to be a timing problem.

32 5Dr.GutHealth, amsterdam_pete, LondonLisa and 29 others
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