Bimagrumab + semaglutide — my results so far

TrialTracker_MD said:

Order of operations matters more than any single choice here: establish a baseline, change one thing, wait long enough for it to express itself, then…

Agreed, though "tolerable" needs defining. A dose you tolerate by eating almost nothing is not tolerated, it is being paid for somewhere else — usually in lean mass, sometimes in adherence three months later.

That is the short version; the long version is somebody else's post.

NicoleRaleigh said:

The dose-response is real but shallow at the top.

Bookmarking. The distinction being drawn above is the one nobody else makes.

TrialTracker_MD said:

Order of operations matters more than any single choice here: establish a baseline, change one thing, wait long enough for it to express itself, then…

This is where I part company with the consensus forming above. The trial means are being read too generously in this thread. STEP populations were selected, supported, and titrated by protocol, and the real-world curves are consistently a few points worse. That difference is not noise, it is what happens when you remove the study infrastructure.

One concrete data point for the thread. One habit that pays for itself: post the method alongside the number. A figure without its method cannot be checked, and an unchecked figure is how this community accumulates folklore.

I would rather be corrected than agreed with, if it comes to it.

Moderator note: two posts asking for a source have been merged into one. Please search the thread before asking again.