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ForumsPublic SquareCost-effectiveness analysis: GLP-1 agonists vs bariatric surgery (ICER 2026) — March 2026

Cost-effectiveness analysis: GLP-1 agonists vs bariatric surgery (ICER 2026) — March 2026

Dr.EndoEP Thu, Mar 7, 2024 at 5:14 PM 15 replies 2,066 viewsPage 1 of 3
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Dr.EndoEP
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Mar 7, 2024 at 5:14 PM#1

Collecting this in one place because it comes up every few weeks and the answer is always assembled from scratch. It is about surgery and anaesthesia, and it is deliberately narrow — everything I am not confident about is marked as such.

What is actually established

This is the one where the stakes are high and the answer is simple: tell the anaesthetist. Delayed gastric emptying means a stomach that is not empty after a standard fast, and that is an aspiration risk under anaesthesia. Current guidance is broadly to hold weekly agents for about a week before an elective procedure and daily agents for a day, but the decision belongs to the anaesthetic team and they can only make it if they know.

The condition it depends on

Agreed. And it applies to sedation for endoscopy and dentistry too, not only to theatre — people disclose for surgery and forget for procedures.

What I am not sure about

What would genuinely help is knowing how long before a procedure people were told to hold, and whether the interval differs between the weekly and daily agents. Numbers rather than impressions, if you have them.

— Dr.EndoEP · corrections welcome and will be edited into this post with credit
9 12NicoleRaleigh, james_edin, FranDenver and 6 others
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DanielChem_CHI
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Mar 7, 2024 at 5:24 PM#2
Dr.EndoEP said:
This is the one where the stakes are high and the answer is simple: tell the anaesthetist.

Agreed, and coverage criteria are plan-specific rather than insurer-specific. Two people with the same insurer and different employers have different rules, which is why "my insurer covers it" is not transferable information.

Last edited: Mar 7, 2024 at 7:24 PM
10 13Dr.DermMIA, fiona_VT, denise_HTX and 7 others
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Dr.ObesityMed
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Mar 7, 2024 at 5:34 PM#3
Dr.EndoEP said:
This is the one where the stakes are high and the answer is simple: tell the anaesthetist.

Pushing back on Dr.EndoEP here. Guidance here is not settled and varies by institution, so quoting one society's interval as the rule is misleading. The invariant part is disclosure, not the number of days.

Last edited: Mar 7, 2024 at 11:34 PM
11 14SurmountFan_IN, PeptideChemSF, A1cHero_PHX and 8 others
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Dr.EM_Chicago
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Mar 7, 2024 at 5:44 PM#4

Short answer first, then the reasoning. Denials are usually procedural rather than clinical, and the order that works reflects that. Get the denial reason in writing, because it names the criterion you failed. Then supply the documentation that criterion asks for — usually documented BMI with a comorbidity, or a failed prior therapy. Then appeal, and ask for a peer-to-peer review, because a prescriber talking to a reviewing clinician resolves a large fraction of denials that written appeals do not. Manufacturer copay assistance is separate and applies mainly to commercial insurance, and patient assistance programmes are means-tested rather than a discount.

Last edited: Mar 7, 2024 at 9:44 PM
12 15lucas_SP_BR, lisa_labSD, adam_van and 9 others
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Dr.PulmRoch
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Mar 7, 2024 at 6:38 PM#5
DanielChem_CHI said:
Agreed, and coverage criteria are plan-specific rather than insurer-specific.

Can confirm. Same sequence, different timescale. The detail I would add is minor and it is already implied above.

13 16KristenIndy, MarkLI_maint, Dr.PeteFamMed and 10 others
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