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ForumsRetatrutide & Triple AgonistsTRIUMPH program trial design overview — all Phase 3 arms Page 5

TRIUMPH program trial design overview — all Phase 3 arms

TrialTracker_MD Mon, Feb 26, 2024 at 4:00 PM 324 replies 45,778 viewsPage 5 of 20
Dr.RaviCardio
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Mar 9, 2024 at 7:41 AM#21

Clinical perspective, offered as context rather than as advice. If two explanations both fit, the useful question is which one predicts something the other does not. That is answerable; arguing about which sounds more plausible is not.

1 1pete_manc_UK
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CryptoCarl
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Mar 12, 2024 at 11:40 PM#22
Dr.RaviCardio said:
If two explanations both fit, the useful question is which one predicts something the other does not.

Same pattern here, and in the same order.

50 0MariaRD, AussieAnna, BethLabQueen and 47 others
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Dr.RheumBOS
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Mar 16, 2024 at 3:36 PM#23
Dr.RaviCardio said:
If two explanations both fit, the useful question is which one predicts something the other does not.

Coming at Dr.RaviCardio’s question from a different direction. The gap between trial results and real-world results is consistent and it is not fraud. Trial participants get titration by protocol, scheduled contact, free drug and dietetic support; removing that infrastructure costs a few percentage points every time it has been measured. When your own curve sits below the published mean, that is the likeliest explanation before anything about you or your material.

That is the short version; the long version is somebody else's post.

Last edited: Mar 16, 2024 at 9:36 PM
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BiostatsBrad
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Mar 20, 2024 at 7:30 AM#24

The figures, for anyone assembling their own picture. For anyone reading later: the numbers in this thread are worth checking against a primary source before you act on them, including mine. Half the figures circulating in this community trace back to a secondary summary that dropped a qualifier.

48 23james_edin, FranDenver, Dr.BariatricHTX and 45 others
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KarenAZ_mom
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Mar 23, 2024 at 11:22 PM#25

Following on from Dr.RaviCardio — and this may be the naive question:

Why adding glucagon agonism to an anti-obesity drug is not self-defeating, given that glucagon raises blood glucose?

47 22HPLC_Greg, LibrarianMeg, bri_stats and 44 others
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