SHBG changes during weight loss on GLP-1 — hormonal implications

Dr.ReproEndo said:

Most of the hormonal change here is a consequence of adiposity falling rather than a drug effect.

HPA axis assessment on the hormone panel: rarely ordered but informative for understanding the stress-metabolism connection:

4-point salivary cortisol:

• Morning: 16 ng/mL → 13 ng/mL (improved)
• Noon: 9 ng/mL → 6 ng/mL
• Evening: 5 ng/mL → 2 ng/mL
• Night: 3 ng/mL → 1 ng/mL

The cortisol curve is normalizing — less flat, better diurnal variation. Reduced visceral fat = reduced cortisol overproduction. The metabolic benefits cascade into stress hormone regulation.

Dr.ReproEndo said:

Most of the hormonal change here is a consequence of adiposity falling rather than a drug effect.

Hormone panel changes on the hormone panel — relevant for anyone curious about endocrine effects:

• Testosterone: increased 42% (weight loss reduces aromatase in adipose tissue)
• Estradiol: normalized from elevated baseline
• SHBG: increased appropriately
• Free testosterone: increased 18%
• Cortisol AM: within normal limits, no significant change

My reproductive endocrinologist says the testosterone improvement alone could explain the energy and mood benefits I've experienced.

LibrarianMeg said:

Hormone panel changes on the hormone panel — relevant for anyone curious about endocrine effects: Testosterone: increased 42% (weight loss reduces…

Sex hormone labs after weight loss on the hormone panel — for the men in this thread:

Testosterone: 341 → 621 ng/dL (dramatic improvement!)
Free T: 5.6 → 13.1 ng/dL
Estradiol: 53 → 27 pg/mL
SHBG: 23 → 43 nmol/L

Visceral fat contains aromatase which converts testosterone to estrogen. As you lose visceral fat, this conversion decreases and testosterone naturally rises. I feel 10 years younger.

BenResearch_OR said:

HPA axis assessment on the hormone panel: rarely ordered but informative for understanding the stress-metabolism connection: 4-point salivary…

Same experience, arrived at from the opposite direction. I had assumed I was the exception until I read this.