Novo Nordisk CagriSema Phase 3 results — what worked for you?

Answering the narrow version, because the broad one does not have a single answer. The gap between trial results and real-world results is consistent and it is not fraud. Trial participants get titration by protocol, scheduled contact, free drug and dietetic support; removing that infrastructure costs a few percentage points every time it has been measured. When your own curve sits below the published mean, that is the likeliest explanation before anything about you or your material.

LipidDoc_ATL said:

The gap between trial results and real-world results is consistent and it is not fraud.

Agreed, and subgroup analyses deserve particular suspicion. With enough subgroups something is significant by chance, and pre-registered subgroups are a different animal from ones found afterwards.

tommy_boulder said:

Trying to work out whether the combination is doing something a higher single-agent dose would not, or whether it is a more expensive way to reach the…

Same experience, arrived at from the opposite direction. Nothing to add that would improve it.

Adding the clinical framing, because it changes how the question reads. It is worth asking what the claim would look like if it were false. If nothing would look different, it is not a claim about the world and no amount of discussion will settle it.