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ForumsLab Results & BiomarkersLiver enzymes trending down on GLP-1 — ALT/AST normalization Page 4

Liver enzymes trending down on GLP-1 — ALT/AST normalization

MASHdoc_SA Sun, Jun 7, 2026 at 5:07 PM 17 replies 389 viewsPage 4 of 4
DebRD_ATL
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Jun 8, 2026 at 2:43 PM#16
Dr.RaviCardio said:
There is a difference between no evidence and evidence of no effect, and this subject is one where the two get swapped freely in both directions.

Same experience, arrived at from the opposite direction.

Last edited: Jun 8, 2026 at 6:43 PM
43 18BiostatsBrad, PeptideSynthNJ, Dr.KarenChen and 40 others
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labquiet_amy
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Jun 8, 2026 at 4:25 PM#17
BethLabQueen said:
The boring version of this is the one that works, and the boring version is: measure a baseline, change one variable, wait, measure again under the…

That holds where the measurement is reliable. Where it is noisy — and a lot of what gets tracked here is noisy — the same reasoning produces confident nonsense.

I would rather be corrected than agreed with, if it comes to it.

42 17HPLC_Greg, LibrarianMeg, bri_stats and 39 others
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roxy_nash
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Jun 8, 2026 at 6:07 PM#18
BethLabQueen said:
The boring version of this is the one that works, and the boring version is: measure a baseline, change one variable, wait, measure again under the…

This answered a question I did not know how to ask. Adding it to my notes with a link back to this thread.

41 16tony_orlando, Dr.NephBHM_UK, kim_atl_prep and 38 others
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Dr.RheumBOS
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Jun 8, 2026 at 7:49 PM#19

Adding the clinical framing, because it changes how the question reads. Order of operations matters more than any single choice here: establish a baseline, change one thing, wait long enough for it to express itself, then measure again under the same conditions.

40 15lori_vegas, Dr.PulmRoch, maya_sedona and 37 others
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Admin
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Jun 8, 2026 at 9:32 PM#20

Moderator note: the sourcing question belongs in the vendor section and has been split out. Report rather than reply if it drifts again.

18 18PeptideSynthNJ, Dr.KarenChen, Dr.NateNeph and 15 others
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