🍪 The GLP Lounge uses cookies to improve your experience, analyze traffic, and personalize content. By continuing to use this site, you agree to our Cookie Policy.
Evidence-based GLP-1 & peptide discussion since 2023
ForumsClinical Trials & ResearchInsulin icodec (Awiqli) — weekly basal insulin + GLP-1 combo potential

Insulin icodec (Awiqli) — weekly basal insulin + GLP-1 combo potential

Dr.MetabolicMD Sat, May 23, 2026 at 9:23 AM 15 replies 431 viewsPage 1 of 3
Dr.MetabolicMD
VIP Member
2,345
16,789
Jan 2024
Rochester, MN
May 23, 2026 at 9:23 AM#1

Putting this up for argument rather than for agreement. I have read it twice and I am still not certain what it supports.

Read four things before the headline number. The population, because trial populations are selected and supported in ways that real cohorts are not. The comparator, because "better than placebo" and "better than the current standard" are different claims and get reported identically. The primary endpoint as pre-registered, because a secondary endpoint promoted after the fact is a hypothesis rather than a finding. And the completion rate, because a large effect in the half of participants who finished is a different result from a large effect in everybody enrolled.

Where I think it is weakest: the follow-up is short relative to how long people actually take these drugs, so durability is an assumption here rather than a finding.

The bit I cannot resolve on my own is how to read a result like this without either dismissing it or over-reading it, since the summaries all read like press releases. Numbers rather than impressions, if you have them.

Note on sourcing:
Figures above are from the primary publication rather than the press summary. If a number here disagrees with one you have, post yours and we will work out which of us is reading a secondary source.
46 24SleepDoc_PDX, RegAffairsDC, BiostatsBrad and 43 others
Reply Quote Save Share Report
VendorMark
Senior Member
3,456
14,567
Jan 2024
Texas
Online
May 23, 2026 at 10:18 AM#2
Dr.MetabolicMD said:
Read four things before the headline number.

Agreeing with Dr.MetabolicMD, and the qualification matters more than the agreement. Relative and absolute effects need reading together. A 20% relative reduction on a high baseline risk is a large absolute benefit; the same relative figure on a low baseline risk is a small one, and press summaries almost always quote the relative number because it is bigger.

Last edited: May 23, 2026 at 12:18 PM
47 0KristenIndy, MarkLI_maint, Dr.PeteFamMed and 44 others
Reply Quote Save Share Report
Dr.NutriCornell
Senior Member
1,345
6,234
Mar 2024
Ithaca, NY
May 23, 2026 at 11:13 AM#3
Dr.MetabolicMD said:
Read four things before the headline number.

Pushing back on Dr.MetabolicMD here. I would add the less popular caveat: these trial populations under-represented several groups, older adults and the highest BMI categories among them. The results probably generalise, and "probably" should be stated as an assumption rather than dropped.

48 1laura_annarbor, JenMemphis, pat_auckland and 45 others
Reply Quote Save Share Report

Sigma-Aldrich — Research-Grade Standards

Certified reference materials, analytical reagents, and research-grade standards for peptide verification. Trusted by laboratories worldwide.

Shop Reference Standards
Dr.BariatricHTX
Senior Member
1,456
7,234
Feb 2024
Houston, TX
May 23, 2026 at 12:08 PM#4

Taking the question as asked, rather than the general version of it. The gap between trial results and real-world results is consistent and it is not fraud. Trial participants get titration by protocol, scheduled contact, free drug and dietetic support; removing that infrastructure costs a few percentage points every time it has been measured. When your own curve sits below the published mean, that is the likeliest explanation before anything about you or your material.

Last edited: May 23, 2026 at 6:08 PM
49 2stefan_berlin, Dr.EM_Chicago, pete_RVA and 46 others
Reply Quote Save Share Report
jim_asheville
Member
289
1,234
Aug 2024
Asheville, NC
May 23, 2026 at 5:23 PM#5
VendorMark said:
Relative and absolute effects need reading together.

Mine went the same way, slower. The detail I would add is minor and it is already implied above.

50 3LarryQC_SD, wanda_boise, NurseAsh_DET and 47 others
Reply Quote Save Share Report

Similar Threads

FLOW trial: semaglutide renal outcomes — NEJM publication review14 replies
SELECT trial: semaglutide 2.4mg cardiovascular outcomes — 4yr data9 replies
TRIUMPH program (retatrutide) — Phase 3 trial design and endpoints13 replies
Orforglipron ATTAIN trials — oral non-peptide GLP-1 agonist8 replies
CagriSema (amylin + semaglutide) — REDEFINE Phase 3 results20 replies
ForumsNewTrendingMembersAccount

Log In

Forgot password?
No account? Register