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ForumsTirzepatide (Mounjaro / Zepbound)Has anyone dealt with tirzepatide and fatty liver? Page 3

Has anyone dealt with tirzepatide and fatty liver?

Dr.PeteFamMed Tue, Nov 18, 2025 at 6:29 PM 39 replies 1,964 viewsPage 3 of 8
BethLabQueen
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Nov 19, 2025 at 6:33 AM#11
DeniseRN_TPA said:
The liver data is among the strongest non-weight findings in the class.

Agreed, and ALT falling is not the same as fibrosis improving. Enzymes are a crude proxy; FIB-4 or elastography is what tells you about the thing that matters.

Last edited: Nov 19, 2025 at 7:33 AM
20 20maya_sedona, stefan_berlin, Dr.EM_Chicago and 17 others
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KarenAZ_mom
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Nov 19, 2025 at 1:15 PM#12
pete_RVA said:
True, though the ladder is longer and that is not a neutral detail — six dose steps means six opportunities to stall on the way up, and plenty of…

Genuinely useful, thank you. I had the facts and not the framework. I will report back once I have actually tried it.

19 19pete_manc_UK, anna.melb_AU, mark_tokyo and 16 others
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sarah_TO
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Nov 19, 2025 at 7:57 PM#13
DeniseRN_TPA said:
The liver data is among the strongest non-weight findings in the class.

Pushing back on DeniseRN_TPA here. I think the framing smuggles in the conclusion. Ask it the other way round and the obvious answer reverses, which usually means the question is doing the work.

Worth separating that from liver and MASH, which this thread keeps folding into the same question. They behave differently and the advice does not transfer.

18 18GraceAZ_72, carl_compliance, DanielChem_CHI and 15 others
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BiostatsBrad
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Nov 20, 2025 at 2:40 AM#14

The figures, for anyone assembling their own picture. For anyone reading later: the numbers in this thread are worth checking against a primary source before you act on them, including mine. Half the figures circulating in this community trace back to a secondary summary that dropped a qualifier.

Worth separating that from liver and MASH, which this thread keeps folding into the same question. They behave differently and the advice does not transfer.

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mike_mod
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Nov 20, 2025 at 9:23 AM#15

Moderator note: two posts asking for a source have been merged into one. Please search the thread before asking again. Thread quality here is what the rules are for. Keep it up.

16 16PurityPaulOR, MaxMetOK, MounjBrad and 13 others
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