Needle gauge and dead space — March 2026

Following on from anders_CPH — and this may be the naive question:

What did you change at the same time, and can you separate the two now?

BiostatsBrad said:

Say what you would expect to see if you were wrong, before you look.

I read this differently from BiostatsBrad, on substance rather than tone. This treats a plausible mechanism as a demonstrated one. Plausible is where you start looking, not where you stop.

Moderator note: leaving this open. It is being argued well and the disagreement is the useful part. No action needed from anybody.

BiostatsBrad said:

Say what you would expect to see if you were wrong, before you look.

Bookmarking. The distinction being drawn above is the one nobody else makes. I will report back once I have actually tried it.

Adding the clinical framing, because it changes how the question reads. Order of operations matters more than any single choice here: establish a baseline, change one thing, wait long enough for it to express itself, then measure again under the same conditions.