Dr.MetabolicMD said:There is a difference between no evidence and evidence of no effect, and this subject is one where the two get swapped freely in both directions.
Bookmarking. The distinction being drawn above is the one nobody else makes.
From the other side of the consultation, briefly. The mechanism and the magnitude are separate questions. Agreeing that something happens says nothing about whether it happens enough to act on.
Dr.DermMIA said:If two explanations both fit, the useful question is which one predicts something the other does not.
Filing a mild objection. Mild because I might be wrong; an objection because nobody has addressed the case that does not fit. I think the framing smuggles in the conclusion. Ask it the other way round and the obvious answer reverses, which usually means the question is doing the work.
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Shop Reference StandardsOne concrete data point for the thread. If you are going to change something, change one thing and give it long enough to express itself. Four weeks is the usual minimum for anything pharmacological on this board, and two weeks of data has told you almost nothing.
Moderator note: good thread. Keeping it here rather than moving it, because the question is general enough to be useful. Tagging this one for the weekly digest.