SURMOUNT-OSA: tirzepatide and sleep apnea AHI reduction — 6 month update

Dr.AddMedPHL said:

SURMOUNT-1 landed around 20.9% mean weight loss at 15mg over 72 weeks, against roughly 15% for semaglutide 2.4mg in STEP 1.

Month 6 update on sleep apnoea: down 33 lbs from my starting weight of 258 lbs. Here's what's changed beyond the scale:

• No longer pre-diabetic (A1C normalized)
• Off blood pressure medication
• Can tie my shoes without getting winded
• Sleep apnea resolved — returned my CPAP
• Confidence level: through the roof

This medication has genuinely given me my life back. I'm not exaggerating. 🙌

FitDadDave said:

True, though the ladder is longer and that is not a neutral detail — six dose steps means six opportunities to stall on the way up, and plenty of…

This is exactly what I could not find anywhere else. Taking it to my next appointment.

Dr.AddMedPHL said:

SURMOUNT-1 landed around 20.9% mean weight loss at 15mg over 72 weeks, against roughly 15% for semaglutide 2.4mg in STEP 1.

I read this differently. The confidence in this thread is running ahead of the evidence, and I would rather the uncertainty were stated than smoothed over because it is unsatisfying.

Adding the numbers, since they settle part of this. Keep the original post as written when you update it, and add the correction underneath. An edited-away mistake is invisible to the next person who makes it.

Moderator note: the sourcing question belongs in the vendor section and has been split out.