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ForumsPsychological & BehavioralCognitive effects of GLP-1 agonists — need advice

Cognitive effects of GLP-1 agonists — need advice

raj_cambridge Thu, Oct 31, 2024 at 7:10 AM 35 replies 2,036 viewsPage 1 of 7
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raj_cambridge
Member
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Jun 2024
Cambridge, MA
Oct 31, 2024 at 7:10 AM#1

The weight came off and the harder part started, which is not what any of the material I read had prepared me for.

What I am trying to establish is how people separated a drug effect from the ordinary consequences of a large deficit and disrupted sleep, because I cannot.

I have searched first, so if this is covered somewhere point me at it and I will read it.

13 16SleepFixSam, PurityPaulOR, MaxMetOK and 10 others
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BenResearch_OR
Senior Member
2,456
11,234
Dec 2023
Oregon
Oct 31, 2024 at 7:17 AM#2
raj_cambridge said:
The weight came off and the harder part started, which is not what any of the material I read had prepared me for.

One year anniversary on mental health — reflections:

What I wish I'd known: the side effects are temporary, the benefits compound over time, protein is more important than I thought, and the mental health aspect needs as much attention as the physical.

What surprised me: how much my relationship with food changed, the cascade of health improvements beyond weight, and how supportive this community is.

What I'd do differently: start therapy earlier, prioritize resistance training from day 1, and stop comparing my progress to others. Everyone's journey is unique.

14 17PharmD_Rodriguez, julia.endo, JessicaM_2024 and 11 others
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pete_RVA
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178
890
Dec 2024
Richmond, VA
Oct 31, 2024 at 7:24 AM#3
BenResearch_OR said:
One year anniversary on mental health — reflections: What I wish I'd known: the side effects are temporary, the benefits compound over time, protein…

When to call your doctor about mental health side effects — a reference I wish I'd had:

Call immediately:

  • Severe abdominal pain (could be pancreatitis)
  • Vision changes (thyroid concern)
  • Lump in neck (thyroid nodule)
  • Severe vomiting/can't keep fluids down for 24h+

Schedule an appointment:

  • Persistent nausea beyond 4 weeks
  • Significant hair loss
  • Mood changes or depression
  • Gallbladder symptoms (RUQ pain after eating)
15 18Admin, Dr.Martinez, mike_mod and 12 others
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AussieAnna
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Jun 2024
Sydney, AU
Oct 31, 2024 at 7:31 AM#4
raj_cambridge said:
The weight came off and the harder part started, which is not what any of the material I read had prepared me for.

This is my experience too, for whatever a second data point is worth. Nothing to add that would improve it.

16 19bri_stats, pete_manc_UK, anna.melb_AU and 13 others
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EndoResFellow
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Sep 2024
Baltimore, MD
Oct 31, 2024 at 8:09 AM#5

Adding the clinical framing, because it changes how the question reads.

raj_cambridge said:
...mental health should only be used alongside therapy...

I'd say therapy should be AVAILABLE to all GLP-1 patients, but requiring it as a precondition for treatment would create an access barrier.

Not everyone can afford therapy. Not everyone needs it. Some people do just fine with medication + lifestyle changes. But for those with emotional eating, body image issues, or disordered eating history, therapy is extremely valuable.

My recommendation: make mental health screening part of the initial assessment, offer therapy as a recommended adjunct, but don't gatekeep medication access behind it.

17 20Dr.ObesityLA, NurseKim_ATL, paul_denver and 14 others
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