Tirzepatide and sulfur burps: GIP receptor-mediated gastric effects — looking for input

LipidDoc_ATL said:

Dose-response modeling for tirzepatide: Emax model fitting to the STEP/SURMOUNT dose-finding data shows: Semaglutide: ED50 ≈ 0.6mg, Emax ≈ -18%, Hill…

Agreed on adaptation, with a caveat: adaptation applies to gastric emptying and not to everything. If your problem is the aversion rather than the fullness, waiting does less, because the aversion is central and it is the mechanism working as intended.

Dr.PeteFamMed said:

Agreed on adaptation, with a caveat: adaptation applies to gastric emptying and not to everything.

Can confirm. Same sequence, different timescale. Nothing to add that would improve it.

Dr.PeteFamMed said:

Agreed on adaptation, with a caveat: adaptation applies to gastric emptying and not to everything.

There is a second half to this that has not been said yet. Most of what circulates confidently in this community traces back to one summary of one study, and the qualifier was dropped somewhere in the third retelling.

One concrete data point for the thread. Keep the original post as written when you update it, and add the correction underneath. An edited-away mistake is invisible to the next person who makes it.

Moderator note: leaving this open. It is being argued well and the disagreement is the useful part. Report rather than reply if it drifts again.