Endotoxin testing in compounded injectables — looking for input

Dr.AddMedPHL said:

Regarding compounded supply compounding legality: compounding pharmacies can legally produce semaglutide and tirzepatide while these drugs remain on…

This is exactly what I could not find anywhere else.

From the other side of the consultation, briefly.

I have been on both brand and compounded, and in the context of compounded supply, my experience has been equivalent with both. The key is finding a reliable 503B pharmacy with independent testing.

Dr.SurgeonPGH said:

I have been on both brand and compounded, and in the context of compounded supply, my experience has been equivalent with both.

Second this. Nothing to add that would improve it.

Dr.SurgeonPGH said:

I have been on both brand and compounded, and in the context of compounded supply, my experience has been equivalent with both.

Vendor communication red flags for compounded supply:

• Won't provide COA before purchase — walk away
• Claims "100% pure" without analytical data — unrealistic
• No physical address or phone number — accountability matters
• Pushes you to buy more than you need — pressure tactics
• Won't answer questions about their compounding process — transparency is key
• Payment only via crypto or wire transfer — legitimate pharmacies accept cards

A legitimate compounding pharmacy operates like a healthcare business, not a gray market dealer.

Dr.SurgeonPGH said:

I have been on both brand and compounded, and in the context of compounded supply, my experience has been equivalent with both.

FDA inspection results for compounding pharmacies selling compounded supply: you can look up any 503B facility's FDA inspection history on the FDA website.

Check for: Form 483 observations (violations), warning letters, and recall history. A clean inspection record is a strong indicator of quality. My pharmacy has had 0 Form 483 observations in their last 4 inspections.

This is public information. Use it. Link: fda.gov/inspections-compliance-enforcement-and-criminal-investigations