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ForumsPsychological & BehavioralAnyone else feel guilty for using a drug to lose weight? — anyone have experience?

Anyone else feel guilty for using a drug to lose weight? — anyone have experience?

Dr.GastroMayo Wed, Mar 5, 2025 at 3:04 PM 6 replies 1,583 viewsPage 1 of 2
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Dr.GastroMayo
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Mayo Clinic, MN
Mar 5, 2025 at 3:04 PM#1

My mood has been flatter since about month four and I genuinely cannot work out whether that is the drug, the deficit, or the fact that I no longer have my main coping mechanism.

The question I want answered is how people separated a drug effect from the ordinary consequences of a large deficit and disrupted sleep, because I cannot.

If the honest answer is that nobody knows, that is a useful answer and I would rather have it.

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pete_manc_UK
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Manchester, UK
Mar 5, 2025 at 4:24 PM#2
Dr.GastroMayo said:
My mood has been flatter since about month four and I genuinely cannot work out whether that is the drug, the deficit, or the fact that I no longer…
Dr.GastroMayo said:
...mental health should only be used alongside therapy...

I'd say therapy should be AVAILABLE to all GLP-1 patients, but requiring it as a precondition for treatment would create an access barrier.

Not everyone can afford therapy. Not everyone needs it. Some people do just fine with medication + lifestyle changes. But for those with emotional eating, body image issues, or disordered eating history, therapy is extremely valuable.

My recommendation: make mental health screening part of the initial assessment, offer therapy as a recommended adjunct, but don't gatekeep medication access behind it.

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roxy_nash
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Mar 5, 2025 at 5:44 PM#3
pete_manc_UK said:
Dr.GastroMayo said: ...mental health should only be used alongside therapy...

When to call your doctor about mental health side effects — a reference I wish I'd had:

Call immediately:

  • Severe abdominal pain (could be pancreatitis)
  • Vision changes (thyroid concern)
  • Lump in neck (thyroid nodule)
  • Severe vomiting/can't keep fluids down for 24h+

Schedule an appointment:

  • Persistent nausea beyond 4 weeks
  • Significant hair loss
  • Mood changes or depression
  • Gallbladder symptoms (RUQ pain after eating)
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MikeKY_noInsulin
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Louisville, KY
Mar 5, 2025 at 7:04 PM#4
Dr.GastroMayo said:
My mood has been flatter since about month four and I genuinely cannot work out whether that is the drug, the deficit, or the fact that I no longer…

Adding a me-too, because a thread of one person's experience is not much use.

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Dr.MetabolicMD
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Mar 6, 2025 at 2:50 AM#5

Clinical perspective, offered as context rather than as advice.

Body image adjustment with mental health: I've lost 73 lbs but when I look in the mirror, I still see my old self sometimes. "Phantom fat" is a real phenomenon.

My therapist specializes in body image issues with weight loss patients. She says it can take 12-18 months for your brain's body map to update. In the meantime: take progress photos (your eyes lie but cameras don't), try on old clothes, and be patient with yourself.

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