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ForumsTirzepatide (Mounjaro / Zepbound)Tirz made me a completely different person holy cow Page 5

Tirz made me a completely different person holy cow

ZaraB_AL Thu, Apr 16, 2026 at 7:50 PM 26 replies 743 viewsPage 5 of 6
Dr.NateNeph
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Apr 20, 2026 at 2:10 AM#21

A narrower follow-up, since the general answer is now clear:

How would you tell the difference between that and the alternative explanation?

49 24JakeSmashed95, NauseaFreeNow, SteveThurs and 46 others
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hans_munich
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Apr 20, 2026 at 2:06 PM#22
GenomicsKate said:
Whatever the answer turns out to be, the method for getting there is the same: state the assumption, do the arithmetic in public, and invite the…

I do not accept the framing. The question has been narrowed to the version that has a tidy answer, and the part that was dropped is the part the OP actually asked about.

48 23alex_tucson, kevin_tulsa, Dr.PainCLE and 45 others
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SarahChen_PharmD
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Apr 21, 2026 at 2:01 AM#23
GenomicsKate said:
Whatever the answer turns out to be, the method for getting there is the same: state the assumption, do the arithmetic in public, and invite the…

Agreed, and the size of the effect matters as much as its existence. Something real and small gets treated here as though it were real and decisive.

47 22paul_denver, TinaHashiRN, robert_kc and 44 others
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tommy_boulder
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Apr 21, 2026 at 1:56 PM#24
GenomicsKate said:
Whatever the answer turns out to be, the method for getting there is the same: state the assumption, do the arithmetic in public, and invite the…

That reframing is the part I needed. Printing the relevant bit and taking it with me.

Last edited: Apr 21, 2026 at 2:56 PM
46 21dan_philly, MeganSA_TX, LarryQC_SD and 43 others
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carl_compliance
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Apr 22, 2026 at 1:51 AM#25

Adding the clinical framing, because it changes how the question reads. The honest answer is that the effect is real, the magnitude is contested, and the individual variation is larger than either. Those three things can all be true at once, and most arguments here are two people holding different parts of that.

45 20dave_SLC, FDA_TrackerJim, ricardo_MIA and 42 others
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