MASHdoc_SA said:The mechanism that matters here is not stomach emptying, it is central.
That holds for the injectable. The oral formulation has different absorption behaviour and the dose numbers are not interchangeable, which is worth saying out loud because people quote them as if they were.
KevinCompounds said:All true, with one condition: that curve is for people who reached the dose on schedule.
This is exactly what I could not find anywhere else. Adding it to my notes with a link back to this thread.
MASHdoc_SA said:The mechanism that matters here is not stomach emptying, it is central.
This is where I part company with the consensus forming above. The trial means are being read too generously in this thread. STEP populations were selected, supported, and titrated by protocol, and the real-world curves are consistently a few points worse. That difference is not noise, it is what happens when you remove the study infrastructure.
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Shop Reference Standardssarah.morrison said:The list price and the price I actually pay differ by a factor of six depending on which of four routes I use, and none of that is transparent from…
Insurance update relevant to cost and coverage: I just got my prior auth approved through Blue Cross after 4 attempts.
What finally worked: a letter from my endocrinologist documenting BMI history (>3 years), failed diet attempts, comorbidities (NAFLD + metabolic syndrome), and referencing the SELECT trial data.
If your PA keeps getting denied, don't give up. Request a peer-to-peer review between your doctor and the insurance medical director. That's what finally broke through for me.