CarlaRPh_TPA said:Dose-response modeling for tirzepatide: Emax model fitting to the STEP/SURMOUNT dose-finding data shows: Semaglutide: ED50 ≈ 0.6mg, Emax ≈ -18%, Hill…
Second this.
One thing that is still open after VendorMark’s answer:
Which effects tachyphylax and which persist, because the answer explains why tolerability improves while the appetite effect keeps working?
dave_SLC said:Practical: whatever you change, write down the date and the reason.
Pushing back on dave_SLC here. Not convinced. The evidence being cited is consistent with the conclusion and also consistent with two other conclusions nobody has ruled out.
That is the short version; the long version is somebody else's post.
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View Resultsdave_SLC said:Practical: whatever you change, write down the date and the reason.
True, and it depends on a baseline nobody has stated. Without knowing where someone started, the same number can be an excellent result or a disappointing one.