Clinical perspective, offered as context rather than as advice. It helps to ask what evidence would change your mind before you look at any. If nothing would, the discussion is not about evidence, and it is better to say so early than to spend nine posts discovering it.
Dr.NephBHM_UK said:It helps to ask what evidence would change your mind before you look at any.
Can confirm. Same sequence, different timescale.
Dr.NephBHM_UK said:It helps to ask what evidence would change your mind before you look at any.
Coming at Dr.NephBHM_UK’s question from a different direction. A defensible baseline is short: HbA1c and fasting glucose, a lipid panel with ApoB if you can get it, ALT and AST, creatinine with eGFR, TSH, ferritin and B12, and a full blood count. That set catches the things that change, the things that explain symptoms, and the things that alter the prescribing decision. Almost everything else on the long circulating lists is either invariant, uninterpretable without a specific question, or an incidental finding waiting to cause an unnecessary workup.
If somebody has the primary source to hand I would rather cite it than paraphrase it.
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View ResultsOne concrete data point for the thread. The boring version of this is the one that works, and the boring version is: measure a baseline, change one variable, wait, measure again under the same conditions. Nobody wants that answer and it is still the answer.
Worth separating that from the baseline and follow-up panel, which this thread keeps folding into the same question. They behave differently and the advice does not transfer.
One thing that is still open after Dr.NephBHM_UK’s answer:
How often to repeat it, because quarterly seems to be the convention and I cannot find the reasoning?