Tirzepatide half-life and injection timing — PK data

Dr.GastroMayo said:

Dose-response modeling for tirzepatide: Emax model fitting to the STEP/SURMOUNT dose-finding data shows: Semaglutide: ED50 ≈ 0.6mg, Emax ≈ -18%, Hill…

This is my experience too, for whatever a second data point is worth. I had assumed I was the exception until I read this.

A narrower follow-up, since the general answer is now clear:

Which effects tachyphylax and which persist, because the answer explains why tolerability improves while the appetite effect keeps working?

stefan_berlin said:

If you are going to change something, change one thing and give it long enough to express itself.

I read this differently. The confidence in this thread is running ahead of the evidence, and I would rather the uncertainty were stated than smoothed over because it is unsatisfying.

Worth separating that from the pharmacology, which this thread keeps folding into the same question. They behave differently and the advice does not transfer.

stefan_berlin said:

If you are going to change something, change one thing and give it long enough to express itself.

That holds where the measurement is reliable. Where it is noisy — and a lot of what gets tracked here is noisy — the same reasoning produces confident nonsense.

Moderator note: a couple of off-topic posts removed.