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ForumsPublic SquareNovo Nordisk CagriSema Phase 3 results — need advice Page 6

Novo Nordisk CagriSema Phase 3 results — need advice

mike_mod Tue, Nov 18, 2025 at 8:31 PM 43 replies 1,982 viewsPage 6 of 9
sophie_paris
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Nov 26, 2025 at 11:17 AM#26

From the other side of the consultation, briefly. The useful move here is to separate what is established from what is widely repeated. Those two sets overlap less than the confident tone of most write-ups suggests, and the second set is where nearly all the disagreement on this board comes from.

19 19SallyK_inj, CryptoCarl, MariaRD and 16 others
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Dr.RheumBOS
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Nov 27, 2025 at 9:00 AM#27
sophie_paris said:
The useful move here is to separate what is established from what is widely repeated.

Adding a me-too, because a thread of one person's experience is not much use.

Last edited: Nov 27, 2025 at 3:00 PM
18 18wei_SG, cory_ATX, lori_vegas and 15 others
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TomFromTexas
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Nov 28, 2025 at 6:43 AM#28
sophie_paris said:
The useful move here is to separate what is established from what is widely repeated.

Coming at sophie_paris’s question from a different direction. Relative and absolute effects need reading together. A 20% relative reduction on a high baseline risk is a large absolute benefit; the same relative figure on a low baseline risk is a small one, and press summaries almost always quote the relative number because it is bigger.

Last edited: Nov 28, 2025 at 8:43 AM
17 17Dr.KarenChen, Dr.NateNeph, PharmD_Rodriguez and 14 others
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PeptideSynthNJ
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Nov 29, 2025 at 4:27 AM#29

The figures, for anyone assembling their own picture. For anyone reading later: the numbers in this thread are worth checking against a primary source before you act on them, including mine. Half the figures circulating in this community trace back to a secondary summary that dropped a qualifier.

Correct me if the detail matters more than I have assumed.

Last edited: Nov 29, 2025 at 8:27 AM
16 16MikeKY_noInsulin, Dr.RaviCardio, jennifer_SEA and 13 others
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mike_mod
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Nov 30, 2025 at 2:11 AM#30

Closing the loop on my own question.

Update — my curve sits below the published mean and the explanation is that the trial arm had support I do not have. That was reassuring rather than otherwise.

44 19PurityPaulOR, MaxMetOK, MounjBrad and 41 others
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