Novo Nordisk CagriSema Phase 3 results — need advice

anders_CPH said:

Read four things before the headline number.

Correct, and worth adding that it is reversible. Nothing being described here is a one-way door, which changes how cautious it is reasonable to be.

JessicaH_TX said:

Agreed, and subgroup analyses deserve particular suspicion.

Saving this. It is the first explanation that did not require me to already understand it. Printing the relevant bit and taking it with me.

anders_CPH said:

Read four things before the headline number.

Pushing back on anders_CPH here. I would add the less popular caveat: these trial populations under-represented several groups, older adults and the highest BMI categories among them. The results probably generalise, and "probably" should be stated as an assumption rather than dropped.

Adding the numbers, since they settle part of this. Keep the original post as written when you update it, and add the correction underneath. An edited-away mistake is invisible to the next person who makes it.

Moderator note: reminder that nothing in this thread is medical advice, and that clinical claims need a source. No action needed from anybody.