Dr.NateNeph said:SURMOUNT-1 landed around 20.9% mean weight loss at 15mg over 72 weeks, against roughly 15% for semaglutide 2.4mg in STEP 1.
This is exactly what I could not find anywhere else. Taking it to my next appointment.
Clinical perspective, offered as context rather than as advice.
Comprehensive lipid panel update relevant to the lipid panel:
| Marker | Baseline | 6 Months | 12 Months | Reference |
|---|---|---|---|---|
| Total Cholesterol | 259 | 214 | 184 | <200 |
| LDL | 164 | 119 | 104 | <100 |
| HDL | 47 | 46 | 56 | >40 |
| Triglycerides | 239 | 174 | 114 | <150 |
| LDL-P | 1679 | 1129 | 929 | <1000 |
The triglyceride drop is the most impressive. My cardiologist reduced my statin dose based on these results.
Dr.GutHealth said:The GIP arm is doing real work rather than padding the label.
I read this differently from Dr.GutHealth, on substance rather than tone. The "tirzepatide is simply better" summary irritates me. It is better on mean weight loss, and the cardiovascular outcome evidence is far thinner than semaglutide's. If the reason for treating is cardiovascular risk rather than weight, the evidence base points the other way.
Community-driven peptide testing and vendor rating platform. Transparent results. Unbiased analysis. Trusted by thousands.
View ResultsDr.LipidDallas said:ApoB is the more informative number and it is cheap.
Before/after bloodwork compilation for the lipid panel — everything in one place for those who want comprehensive data:
| Category | Marker | Before | After 12mo | Change |
|---|---|---|---|---|
| Metabolic | A1C | 8.2% | 5.4% | ⬇️ 1.4% |
| Metabolic | Fasting Glucose | 121 | 89 | ⬇️ 31 |
| Lipids | LDL | 154 | 98 | ⬇️ 56 |
| Lipids | Triglycerides | 256 | 111 | ⬇️ 126 |
| Inflammation | hsCRP | 5.5 | 0.9 | ⬇️ 4.0 |
Every single metabolic marker improved. This is why I'm a believer in this therapy.
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