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ForumsPsychological & BehavioralThe psychological adjustment to rapid weight loss — need advice Page 2

The psychological adjustment to rapid weight loss — need advice

denise_HTX Fri, Sep 19, 2025 at 2:06 AM 40 replies 1,403 viewsPage 2 of 8
TrialTracker_MD
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Sep 19, 2025 at 3:24 AM#6
PharmD_Rodriguez said:
Anxiety increase on mental health: counterintuitive, but losing weight rapidly triggered anxiety for me.

Filing a mild objection. Mild because I might be wrong; an objection because nobody has addressed the case that does not fit. I would be careful about how confidently the flatness reports get attributed. Rapid weight loss, a large deficit and disrupted sleep produce low mood on their own, and separating that from a drug effect is genuinely hard.

That is the short version; the long version is somebody else's post.

2 22Dr.EM_Chicago, pete_RVA
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jason_paloalto
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Sep 19, 2025 at 3:54 AM#7
denise_HTX said:
The weight came off and the harder part started, which is not what any of the material I read had prepared me for.

Positive side effects of mental health that surprised me:

  1. Clearer skin — inflammation reduction improved my rosacea
  2. Better sleep — weight loss resolved mild sleep apnea
  3. Improved libido — better body image + improved cardiovascular health
  4. Less joint pain — obvious mechanical benefit
  5. More energy — metabolic improvements across the board

Not everything about GLP-1 therapy is a struggle. There are genuinely wonderful changes too. ✨

1 21Dr.PathRoch
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Dr.KarenChen
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Sep 19, 2025 at 4:24 AM#8
TrialTracker_MD said:
I would be careful about how confidently the flatness reports get attributed.

When to call your doctor about mental health side effects — a reference I wish I'd had:

Call immediately:

  • Severe abdominal pain (could be pancreatitis)
  • Vision changes (thyroid concern)
  • Lump in neck (thyroid nodule)
  • Severe vomiting/can't keep fluids down for 24h+

Schedule an appointment:

  • Persistent nausea beyond 4 weeks
  • Significant hair loss
  • Mood changes or depression
  • Gallbladder symptoms (RUQ pain after eating)
Last edited: Sep 19, 2025 at 10:24 AM
50 20TomFromTexas, mike.trainer_LA, sarah_nash92 and 47 others
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maya_sedona
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Sep 19, 2025 at 4:54 AM#9

One thing that is still open after FitDadDave’s answer:

How long did you give it before you decided it was working?

49 19MikeKY_noInsulin, Dr.RaviCardio, jennifer_SEA and 46 others
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denise_HTX
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Houston, TX
Sep 19, 2025 at 7:17 AM#10

Reporting back.

Update: I got the sleep and the intake sorted before deciding it was the drug, and most of the flatness went with them. Not all of it, and I am watching the rest.

39 14TirzTom, TrialTracker_MD, JennaRN and 36 others
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