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ForumsOral GLP-1 AgonistsOrforglipron Phase 3 ATTAIN-1 topline — need advice Page 3

Orforglipron Phase 3 ATTAIN-1 topline — need advice

TomFromTexas Wed, Jun 12, 2024 at 6:21 PM 14 replies 1,996 viewsPage 3 of 3
PeptideChemSF
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Jun 17, 2024 at 2:12 AM#11
hyun_seoul said:
Read four things before the headline number.

No disagreement, though it depends on where somebody is starting from, and this thread has been assuming a starting point nobody stated.

Happy to go further on any of that.

Last edited: Jun 17, 2024 at 6:12 AM
43 18steve_okc, dave_SLC, FDA_TrackerJim and 40 others
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dan_philly
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Jun 19, 2024 at 5:39 PM#12
raj_cambridge said:
Orforglipron is a small molecule rather than a peptide, which is the whole point: no SNAC absorption enhancer, no fasting window, no cold chain, and…

This is exactly what I could not find anywhere else.

Last edited: Jun 19, 2024 at 8:39 PM
42 17AmyNC_wife, SkepticalSean, Dr.CardioMD and 39 others
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KarenAZ_mom
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Jun 22, 2024 at 9:07 AM#13
hyun_seoul said:
Read four things before the headline number.

I read this differently from hyun_seoul, on substance rather than tone. I would add the less popular caveat: these trial populations under-represented several groups, older adults and the highest BMI categories among them. The results probably generalise, and "probably" should be stated as an assumption rather than dropped.

Last edited: Jun 22, 2024 at 2:07 PM
41 16bri_stats, pete_manc_UK, anna.melb_AU and 38 others
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Dr.PathRoch
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Jun 25, 2024 at 12:36 AM#14

One concrete data point for the thread. Say what you would expect to see if you were wrong, before you look. It is a small discipline and it changes what you notice.

Last edited: Jun 25, 2024 at 6:36 AM
40 15SaraMom3, Dr.MetabolicMD, RetaRick_CA and 37 others
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Admin
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Jun 27, 2024 at 4:07 PM#15

Moderator note: two posts asking for a source have been merged into one. Please search the thread before asking again. Tagging this one for the weekly digest.

39 14PeptideSynthNJ, Dr.KarenChen, Dr.NateNeph and 36 others
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