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ForumsTirzepatide (Mounjaro / Zepbound)SURMOUNT-OSA: tirzepatide and sleep apnea AHI reduction Page 3

SURMOUNT-OSA: tirzepatide and sleep apnea AHI reduction

SleepDoc_PDX Fri, Jun 5, 2026 at 7:06 AM 12 replies 308 viewsPage 3 of 3
bri_stats
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Jun 8, 2026 at 4:35 AM#11
lisa_labSD said:
Steady state is faster than people expect: half-life about five days, so you are at plateau in roughly three to four weeks rather than five.

Genuinely useful, thank you. I had the facts and not the framework. Adding it to my notes with a link back to this thread.

Last edited: Jun 8, 2026 at 8:35 AM
25 0sarah_nash92, FitDadDave, RunnerRach and 22 others
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DebRD_ATL
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Jun 8, 2026 at 7:40 AM#12

Clinical perspective, offered as context rather than as advice.

Sleep changes on sleep apnoea: anyone else sleeping differently? I've been sleeping lighter since starting week 5.

My theory: the weight loss has improved my sleep apnea (confirmed by recent sleep study — AHI dropped from 23 to 4). Better oxygenation at night = better sleep quality = more energy during the day. It's a virtuous cycle.

24 24RegAffairsDC, BiostatsBrad, PeptideSynthNJ and 21 others
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TrialTracker_MD
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Jun 8, 2026 at 10:44 AM#13
Dr.BariatricHTX said:
SURMOUNT-1 landed around 20.9% mean weight loss at 15mg over 72 weeks, against roughly 15% for semaglutide 2.4mg in STEP 1.

Month 16 update on sleep apnoea: down 28 lbs from my starting weight of 253 lbs. Here's what's changed beyond the scale:

  • No longer pre-diabetic (A1C normalized)
  • Off blood pressure medication
  • Can tie my shoes without getting winded
  • Sleep apnea resolved — returned my CPAP
  • Confidence level: through the roof

This medication has genuinely given me my life back. I'm not exaggerating. 🙌

23 23maya_sedona, stefan_berlin, Dr.EM_Chicago and 20 others
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Dr.RaviCardio
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Jun 8, 2026 at 1:49 PM#14

The figures, for anyone assembling their own picture. One practical note: write down what you did and when, before you need it. Reconstructing a timeline from memory three months later is how people end up unable to answer the one question that would have resolved it.

22 22hans_munich, jason_sac26, chris_chi24 and 19 others
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mike_mod
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Jun 8, 2026 at 4:53 PM#15

Moderator note: reminder that nothing in this thread is medical advice, and that clinical claims need a source. Carry on.

21 21PurityPaulOR, MaxMetOK, MounjBrad and 18 others
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